Bleeding related to disturbed fibrinolysis

Bleeding related to disturbed fibrinolysis

The components and reactions of the fibrinolysis system are well understood. The pathway has fewer reactants and interactions than coagulation, but the generation of a complete quantitative model is complicated by the need to work at the solid-liquid interface of fibrin. Diagnostic tools to detect disease states due to malfunctions in the fibrinolysis pathway are also not so well developed as i...

The contribution of fibrinolysis to postbypass bleeding.

E PSILON-AMINOCAPROIC acid prophylactically may have its clinical usefulness.’ “We believe that the most common cause of bleeding after heart surgery is fibrinolysis.“* Such statements have been made recently and similar ones have been intimated by a number of well-respected researchers in anesthesiology and surgery. The routine use of medications affecting coagulation is at the moment limited ...

fibrinolysis in women with heavy menstrual bleeding

Fibrinolysis and the bleeding tendency in patients with hepatosplenic schistosomiasis.

Fifty seven patients with schistosomiasis of the liver and spleen in both the compensated and decompensated states and 15 non-bilharzial subjects were studied. Fibrinogen, plasminogen, fibrinogen/fibrin degradation products, alpha 2-macroglobulin, antithrombin III and Cl-activator concentrations were evaluated in an attempt to assess abnormalities at various stages of the disease. The results s...

Bleeding complications after basilar artery fibrinolysis with tissue plasminogen activator.

BACKGROUND AND PURPOSE Fibrinolysis with local intraarterial urokinase infusion for basilar artery thrombosis has been associated with a low rate of spontaneous symptomatic cerebral hemorrhage, even when patients have been treated late in the course of symptoms. Because urokinase is presently unavailable in the United States, this study was undertaken to determine the frequency of spontaneous c...